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To get a good idea of what histamine can do, let us imagine the effects of an injection of a small amount of histamine: Headache is felt as a pulsating, whole-head pain, often with a sense of pressure.

Fast heart, blood pressure falls, irregular beats with alarming palpitations.

Other H1-antihistamines having an important antimuscarinic activity like diphenhydramine and dimenhydrinate, are used in preventive and curative treatment of motion sickness, but scopolamine which has no antihistamine effect seems more effective than them in preventive treatment.Skin sensations local itching or burning sensation, flushing and a disagreeable heat.Stomach pain acid secretion increases; small intestine contracts with crampy pain Respiratory - nose swelling, congestion, sneezing and wheezing.Histamine is stored in Antihistamines are medications that counteract the effect of the natural chemical histamine.They are valuable drugs to reduce symptoms due to allergic diseases, especially those mediated by histamine.

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